晴朗的一天，激烈的战争再次爆发。汤姆追赶小老鼠杰瑞，后者慌不择路，跑进了一家狗狗收容所。汤姆尾随而入，结果遭到群犬围攻，险些丢掉小命。他惊魂未定躲在收容所门外的大树后面，而杰瑞则悠哉游哉躺在大狗史派克的脖子上养精蓄锐。看着时不时招手气自己的杰瑞，汤姆一腔怒火无处发泄。突然，他看到附近店铺门口有一只黄狗的雕塑。于是一条妙计便在他的脑中生成。汤姆拿掉了假狗的脑袋，套在自己头上，企图混进收容所捉拿杰瑞。不过他的诡计被杰瑞识破，妙趣横生的追逐战便在狗狗收容所内展开了…… 因为剧情多少具有连贯性，因此本片常被看作《保镖（The Bodyguard）》的续集。
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