平凡的一天，汤姆和小老鼠杰瑞再次展开了一场惊险刺激的大混战，虽然木棍、铁棒、铁铲等十八般武器全部用上，但是汤姆根本就不是杰瑞的对手，反而被对方耍得团团转，疲于奔命。万般无奈之下，汤姆根据报纸上的广告向灭鼠公司求助。过了不久，高傲的捕鼠高手幸运小子来了。他先是将一枚螺母做成奶酪的样子，杰瑞果然上当，将其吞到了肚子了，结果被幸运小子抓住。不过杰瑞毕竟是一只身经百战的超级小老鼠，他很快就适应了灭鼠公司的抓捕方式，任凭对方用毒气、炸药或者任何凶器，即使汤姆和幸运小子两人齐上阵也毫不畏惧，更为激烈的战争旋即展开了……
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