在蛮荒的美国西部，夕阳的尽头缓缓行驶着一辆牛车。最前方的是主人公小懒狗德鲁比，他骑着灵巧的小马，肩膀上扛着猎枪匆匆赶路。牛车上坐着德鲁比的太太，太太怀中抱着刚出生不久的小婴儿。有时候小家伙饿的哇哇大哭，德鲁比便从后面的奶牛那里挤来一些奶喂养宝宝。天色渐晚，他们会把车听到大篷车休息站，遇到河流阻道，的路毕业能想出灵巧的办法过河。遇到印第安的时候，德鲁比也能化险为夷。经过一路奔波，他们一家人总算来到一处适合定居的地点，然后开始有条不紊地盖房子。 这个消息很快传到坏心眼的老狼的耳朵里，他决不允许德鲁比一家住在自己的地盘之上……
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